Structure, properties and function of proteins and nucleic acids

Thermodynamics of biomolecules. Calorimetric and spectroscopic studies of the relationship between chemical stability and biological activity. Biocrystallography, multi-dimensional NMR and Mass Spectrometry for the analysis of proteins, oligonucleotides and their complexes. Interactions of proteins with liposomes or membranes. Functional and differential proteomics for the understanding of cellular mechanisms. Quantitative proteomics; optimization of mass spectrometry methods for diagnostics and for the study of  post-translation modifications in proteins. Synthesis, characterization and applications of modified oligonucleotides for anti-sense and anti-gene strategies or as aptamers. Study of DNA unusual conformations and identification of specific ligands. Synthesis of new nucleoside analogs as potential anti-cancer or anti-viral drugs. Qualitative and quantitative identification of stress-induced DNA modifications in bacteria.

Partecipants

  • Amoresano Angela
  • Arciello Angela
  • Birolo Leila
  • Carpentieri Andrea
  • Chino Marco
  • Del Vecchio Pompea
  • Di Fabio Giovanni
  • Duilio Angela
  • Giardina Paola
  • Guaragna Annalisa
  • Leone Serena
  • Lombardi Angelina
  • Merlino Antonello
  • Marchetti Roberta
  • Molinaro Antonio
  • Montesarchio Daniela
  • Monti Daria Maria
  • Monti Maria
  • Musumeci Domenica
  • Nastri Flavia
  • Pavone Vincenzo
  • Pedatella Silvana
  • Petraccone Luigi
  • Piccialli Vincenzo
  • Piccoli Renata
  • Picone Delia
  • Piscitelli Alessandra
  • Pucci Pietro
  • Sica Filomena
  • Silipo Alba
  • Vergara Alessandro