Pharmacology of gaseous transmitters

The gaseous transmitter family includes nitric oxide, carbon monoxide and more recently hydrogen sulfide. These molecules are endogenously produced by enzymatic pathways in mammalian cells and play a key role in several physiological and pathological processes.

Research topics:

  • Gaseous transmitters in cardiovascular system – role of gaseous transmitters in endothelial dysfunction associated to hypertension, hyperhomocysteinemia and/or diabetes.
  • Gaseous transmitters in urogenital tract – role of gaseous transmitters in physiopathology of erectile function and lower urinary tract symptoms.
  • Gaseous transmitters in pulmonary system – role of gaseous transmitters in bronchial hyper-reactivity and pulmonary inflammation.
  • Gaseous transmitters in inflammation and cancer – contribute of gaseous transmitters as signaling molecules in onset and resolution of inflammatory processes.
  • Role of the endogenous pathway involved in the production of hydrogen sulfide in the development and progression of human melanoma.

Partecipants:

  • Cirino Giuseppe
  • Bucci Mariarosaria
  • Ianaro Angela
  • Sorrentino Raffaella
  • d’Emmanuele di Villa Bianca Roberta
  • Roviezzo Fiorentina
  • Panza Elisabetta