Molecular oncology

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Many research teams of the DMMBM are involved in examining either the basic aspects of the regulations of cellular functions or the phenotypic alterations characterizing various cancer types, including thyroid cancers, melanoma and colorectal cancers. These studies focus on DNA replication, transcription and repair, mitosis, apoptosis, signal transduction. Several research projects are also aimed at identifying new targets and cognate active molecules, able to interfere with neoplastic processes. An example of the targets currently studied is the RET proto-oncogene, originally described by DMMBM scientists (see image).
Scientists active in this research area: Acquaviva, Avvedimento, Capasso, Carlomagno, Chiariotti, Condorelli, Costanzo P., Costanzo V., De Lorenzo, De Rosa, De Vita, Esposito F., Feliciello, Fusco, Grieco, Izzo, Melillo, Pierantoni, Santoro, Tramontano, Veneziani, Zollo.